Meyer was born in Queens, New York to a father who owns an auto parts/repair shop. She has two brothers. Meyer loved dancing and acting from an early age, but it was not until after she graduated from university that she started to work to become an actress. She attended Long Island University, where she majored in business administration. Among her hobbies and interests are snowboarding, rollerblading and biking. She lives in Los Angeles. Meyer dated actor Shane West, after the movie A Walk to Remember and also was his date to the premiere.

Meyer's film debut was in the TV film Strapped in 1993, although her role in the cyberpunk thriller Johnny Mnemonic was perhaps her breakthrough performance. Before that, however, she also had a role in the TV series Beverly Hills 90210 as Lucinda Nicholson. In addition to Johnny Mnemonic, she has had other roles in science fiction productions, such as Starship Troopers, Birds of Prey and Star Trek: Nemesis. Three of her most recent films were the 2004 horror/thriller hit Saw, followed by Saw II and its sequel Saw III. She made several guest appearances on Friends and Miss Match. She also played one of the leads on the now canceled Point Pleasant. In March 2006 Meyer was in the series premiere episode of Thief as Wanda the wife of Andre Braugher's character Nick. However, her character was killed in the first episode in a car wreck.

• Beverly Hills 90210 (1990)
• Johnny Mnemonic (1995)
• Dragonheart (1996)
• Starship Troopers (1997)
• Bats (1999)
• Secret Agent Man (2000)
• Birds of Prey (2002)
• Star Trek: Nemesis (2002)
• Saw (2004)
• Point Pleasant (2004)
• Wild Things: Diamonds in the Rough (2005)
• Saw II (2005)
• Saw III (2006)